Quantitative bioluminescence tomography using spectral derivative data
نویسندگان
چکیده
منابع مشابه
Application of Spectral Derivative data in spectral Near Infrared Tomography
The use of the spectral derivative method in Near Infrared optical spectroscopy and tomographic imaging is presented, whereby instead of using discrete measurements around several wavelengths, the difference between nearest neighboring spectral measurements is used. The proposed technique is shown to be insensitive to the unknown tissue and fiber contact coupling coefficients providing substant...
متن کاملTemperature-modulated bioluminescence tomography.
It was recently reported that bioluminescent spectra can be significantly affected by temperature, which we recognize as a major opportunity to overcome the inherent illposedness of bioluminescence tomography (BLT). In this paper, we propose temperature-modulated bioluminescence tomography (TBT) to utilize the temperature dependence of bioluminescence for superior BLT performance. Specifically,...
متن کاملUniqueness theorems in bioluminescence tomography.
Motivated by bioluminescent imaging needs for studies on gene therapy and other applications in the mouse models, a bioluminescence tomography (BLT) system is being developed in the University of Iowa. While the forward imaging model is described by the well-known diffusion equation, the inverse problem is to recover an internal bioluminescent source distribution subject to Cauchy data. Our pri...
متن کاملSpectrally resolved bioluminescence optical tomography.
Spectrally resolved bioluminescence optical tomography is an approach to recover images of luciferase activity within a volume using multiwavelength emission data from internal bioluminescence sources. The underlying problem of uniqueness associated with nonspectrally resolved intensity-based bioluminescence tomography is highlighted. Reconstructed images of bioluminescence are presented by usi...
متن کاملGeometric Reconstruction in Bioluminescence Tomography
In bioluminescence tomography the location as well as the radiation intensity of a photon source (marked cell clusters) inside an organism have to be determined given the outside photon count. This inverse source problem is ill-posed: it suffers not only from strong instability but also from non-uniqueness. To cope with these difficulties the source is modeled as a linear combination of indicat...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biomedical Optics Express
سال: 2018
ISSN: 2156-7085,2156-7085
DOI: 10.1364/boe.9.004163